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  1. Randy Scheckman

    Editor-in-Chief

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    Expertise
    Cell Biology
    Competing interests statement
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  2. Eve Marder

    Deputy Editor

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    Expertise
    Cell Biology
    Competing interests statement
    Donec tellus

About Profiles Compact

Reviewing editors

  1. Editor name

    University of California, Los Angeles (United States)

    Research focus
    Pre-mRNA splicing
    post-transcriptional gene regulation
    Experimental organism
    Human
    Mouse
  2. Editor name

    University of California, Los Angeles (United States)

  3. Editor name

    University of California, Los Angeles (United States)

    Research focus
    Pre-mRNA splicing
    post-transcriptional gene regulation
    Experimental organism
    Human
    Mouse
  4. Editor name

    University of California, Los Angeles (United States)

    Research focus
    Pre-mRNA splicing
    post-transcriptional gene regulation
    Experimental organism
    Human
    Mouse

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some more details here
https://doi.org/10.7554/eLife.10181.001

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Widespread connectivity is not dependent on instrumentation and analyses.

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Many features are conserved between the mammalian nephron and planarian protonephridia.

(A) Image of a young adult C. elegans and schematic depicting the twelve pairs of sensory neurons in the anterior amphid individuals carrying a virus with k deleterious mutations at its endemic equilibrium. class carrying the fewest number of deleterious mutations is defined as mutation class k = 0. Inset: variation in the basic reproductive rate of infected individuals (gray histogram) and variation in the net reproductive rate R of infected individuals (brown histogram) resulting from variation in the number of deleterious mutations carried by circulating viruses.

https://doi.org/10.7554/eLife.14734
https://doi.org/10.7554/eLife.03952.016

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    Oliver Hobert
    Reviewing Editor
    Colombia University, USA
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    Oliver Hobert
    Reviewing Editor
    Colombia University, USA

eLife posts the editorial decision letter and author response on a selection of the published articles (subject to the approval of the authors). An edited version of the letter sent to the authors after peer review is shown, indicating the substantive concerns or comments; minor concerns are not usually shown.

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Listing Annotation Teasers

Annotations

  1. CRIg, a tissue-resident macrophage specific immune checkpoint molecule, promotes immunological tolerance in NOD mice, via a dual role in effector and regulatory T cells
    Retrograde fibroblast growth factor 22 (FGF22) signaling regulates insulin-like growth factor 2 (IGF2) expression for activity-dependent synapse stabilization in the mammalian brain
    What was the Mg2+ concentration?
  2. Clarinet (CLA-1), a novel active zone protein required for synaptic vesicle clustering and release
    Retrograde fibroblast growth factor 22 (FGF22) signaling regulates insulin-like growth factor 2 (IGF2) expression for activity-dependent synapse stabilization in the mammalian brain
  3. Gene free methodology for cell fate dynamics during development
    What was the Mg2+ concentration?
  4. CRIg, a tissue-resident macrophage specific immune checkpoint molecule, promotes immunological tolerance in NOD mice, via a dual role in effector and regulatory T cells
    What was the Mg2+ concentration?
    This is a reply.
  5. Molecular basis of fatty acid taste in Drosophila
    Retrograde fibroblast growth factor 22 (FGF22) signaling regulates insulin-like growth factor 2 (IGF2) expression for activity-dependent synapse stabilization in the mammalian brain
    What was the Mg2+ concentration?
    Only me
  6. CRIg, a tissue-resident macrophage specific immune checkpoint molecule, promotes immunological tolerance in NOD mice, via a dual role in effector and regulatory T cells
    Retrograde fibroblast growth factor 22 (FGF22) signaling regulates insulin-like growth factor 2 (IGF2) expression for activity-dependent synapse stabilization in the mammalian brain
    https://images.pexels.com/photos/707837/pexels-photo-707837.jpeg?w=940&h=650&auto=compress&cs=tinysrgb
  7. CRIg, a tissue-resident macrophage specific immune checkpoint molecule, promotes immunological tolerance in NOD mice, via a dual role in effector and regulatory T cells
    <math xmlns="http://www.w3.org/1998/Math/MathML"><mlongdiv><mn> 12 </mn><mn> 16.5 </mn> <mn> 198 </mn> <msgroup position='1' shift='-1'> <msgroup> <mn> 12</mn> <msline length='2'/> </msgroup> <msgroup> <mn> 78</mn> <mn> 72</mn> <msline length='2'/> <mn> 6.0</mn> <mn> 6.0</mn> </msgroup> <msgroup position='-1'> <!-- extra shift to move to the right of the "." --> <msline length='3'/> <mn> 0</mn> </msgroup> </msgroup> </mlongdiv> </math>
    Long division ftw.
  8. CRIg, a tissue-resident macrophage specific immune checkpoint molecule, promotes immunological tolerance in NOD mice, via a dual role in effector and regulatory T cells
    Retrograde fibroblast growth factor 22 (FGF22) signaling regulates insulin-like growth factor 2 (IGF2) expression for activity-dependent synapse stabilization in the mammalian brain
    https://www.youtube.com/watch?v=oHg5SJYRHA0

Listing Annotation Teasers First Page

Annotations

  1. CRIg, a tissue-resident macrophage specific immune checkpoint molecule, promotes immunological tolerance in NOD mice, via a dual role in effector and regulatory T cells
    Retrograde fibroblast growth factor 22 (FGF22) signaling regulates insulin-like growth factor 2 (IGF2) expression for activity-dependent synapse stabilization in the mammalian brain
    What was the Mg2+ concentration?
  2. Clarinet (CLA-1), a novel active zone protein required for synaptic vesicle clustering and release
    Retrograde fibroblast growth factor 22 (FGF22) signaling regulates insulin-like growth factor 2 (IGF2) expression for activity-dependent synapse stabilization in the mammalian brain
  3. Gene free methodology for cell fate dynamics during development
    What was the Mg2+ concentration?
  4. CRIg, a tissue-resident macrophage specific immune checkpoint molecule, promotes immunological tolerance in NOD mice, via a dual role in effector and regulatory T cells
    What was the Mg2+ concentration?
    This is a reply.
  5. Molecular basis of fatty acid taste in Drosophila
    Retrograde fibroblast growth factor 22 (FGF22) signaling regulates insulin-like growth factor 2 (IGF2) expression for activity-dependent synapse stabilization in the mammalian brain
    What was the Mg2+ concentration?
    Only me
  6. CRIg, a tissue-resident macrophage specific immune checkpoint molecule, promotes immunological tolerance in NOD mice, via a dual role in effector and regulatory T cells
    Retrograde fibroblast growth factor 22 (FGF22) signaling regulates insulin-like growth factor 2 (IGF2) expression for activity-dependent synapse stabilization in the mammalian brain
    https://images.pexels.com/photos/707837/pexels-photo-707837.jpeg?w=940&h=650&auto=compress&cs=tinysrgb
  7. CRIg, a tissue-resident macrophage specific immune checkpoint molecule, promotes immunological tolerance in NOD mice, via a dual role in effector and regulatory T cells
    <math xmlns="http://www.w3.org/1998/Math/MathML"><mlongdiv><mn> 12 </mn><mn> 16.5 </mn> <mn> 198 </mn> <msgroup position='1' shift='-1'> <msgroup> <mn> 12</mn> <msline length='2'/> </msgroup> <msgroup> <mn> 78</mn> <mn> 72</mn> <msline length='2'/> <mn> 6.0</mn> <mn> 6.0</mn> </msgroup> <msgroup position='-1'> <!-- extra shift to move to the right of the "." --> <msline length='3'/> <mn> 0</mn> </msgroup> </msgroup> </mlongdiv> </math>
    Long division ftw.
  8. CRIg, a tissue-resident macrophage specific immune checkpoint molecule, promotes immunological tolerance in NOD mice, via a dual role in effector and regulatory T cells
    Retrograde fibroblast growth factor 22 (FGF22) signaling regulates insulin-like growth factor 2 (IGF2) expression for activity-dependent synapse stabilization in the mammalian brain
    https://www.youtube.com/watch?v=oHg5SJYRHA0

Listing Annotation Teasers Pager

Annotations

  1. CRIg, a tissue-resident macrophage specific immune checkpoint molecule, promotes immunological tolerance in NOD mice, via a dual role in effector and regulatory T cells
    Retrograde fibroblast growth factor 22 (FGF22) signaling regulates insulin-like growth factor 2 (IGF2) expression for activity-dependent synapse stabilization in the mammalian brain
    What was the Mg2+ concentration?
  2. Clarinet (CLA-1), a novel active zone protein required for synaptic vesicle clustering and release
    Retrograde fibroblast growth factor 22 (FGF22) signaling regulates insulin-like growth factor 2 (IGF2) expression for activity-dependent synapse stabilization in the mammalian brain
  3. Gene free methodology for cell fate dynamics during development
    What was the Mg2+ concentration?
  4. CRIg, a tissue-resident macrophage specific immune checkpoint molecule, promotes immunological tolerance in NOD mice, via a dual role in effector and regulatory T cells
    What was the Mg2+ concentration?
    This is a reply.
  5. Molecular basis of fatty acid taste in Drosophila
    Retrograde fibroblast growth factor 22 (FGF22) signaling regulates insulin-like growth factor 2 (IGF2) expression for activity-dependent synapse stabilization in the mammalian brain
    What was the Mg2+ concentration?
    Only me
  6. CRIg, a tissue-resident macrophage specific immune checkpoint molecule, promotes immunological tolerance in NOD mice, via a dual role in effector and regulatory T cells
    Retrograde fibroblast growth factor 22 (FGF22) signaling regulates insulin-like growth factor 2 (IGF2) expression for activity-dependent synapse stabilization in the mammalian brain
    https://images.pexels.com/photos/707837/pexels-photo-707837.jpeg?w=940&h=650&auto=compress&cs=tinysrgb
  7. CRIg, a tissue-resident macrophage specific immune checkpoint molecule, promotes immunological tolerance in NOD mice, via a dual role in effector and regulatory T cells
    <math xmlns="http://www.w3.org/1998/Math/MathML"><mlongdiv><mn> 12 </mn><mn> 16.5 </mn> <mn> 198 </mn> <msgroup position='1' shift='-1'> <msgroup> <mn> 12</mn> <msline length='2'/> </msgroup> <msgroup> <mn> 78</mn> <mn> 72</mn> <msline length='2'/> <mn> 6.0</mn> <mn> 6.0</mn> </msgroup> <msgroup position='-1'> <!-- extra shift to move to the right of the "." --> <msline length='3'/> <mn> 0</mn> </msgroup> </msgroup> </mlongdiv> </math>
    Long division ftw.
  8. CRIg, a tissue-resident macrophage specific immune checkpoint molecule, promotes immunological tolerance in NOD mice, via a dual role in effector and regulatory T cells
    Retrograde fibroblast growth factor 22 (FGF22) signaling regulates insulin-like growth factor 2 (IGF2) expression for activity-dependent synapse stabilization in the mammalian brain
    https://www.youtube.com/watch?v=oHg5SJYRHA0

Listing Profile Snippets

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  1. Meaningful alt text here please.
    Prabhat Jha
    University of Toronto
  2. Meaningful alt text here please.
    Richard Losick
    Harvard University
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Further reading

    1. Cell Biology
    2. Epidemiology and global health
    Lee R Berger
    Research article

    Optimal decision-making requires balancing fast but error-prone and more accurate but slower decisions through adjustments of decision thresholds. Here, we demonstrate two distinct correlates of such speed-accuracy adjustments by recording subthalamic nucleus (STN) activity and electroencephalography in 11 Parkinson’s disease patients during a perceptual decision-making task; STN low-frequency oscillatory (LFO) activity (2–8 Hz), coupled to activity at prefrontal electrode Fz, and STN beta activity (13–30 Hz) coupled to electrodes C3/C4 close to motor cortex. These two correlates differed not only in their cortical topography and spectral characteristics but also in the relative timing of recruitment and in their precise relationship with decision thresholds. Increases of STN LFO power preceding the response predicted increased thresholds only after accuracy instructions, while cue-induced reductions of STN beta power decreased thresholds irrespective of instructions. These findings indicate that distinct neural mechanisms determine whether a decision will be made in haste or with caution.

    1. Cell Biology
    2. Epidemiology and global health
    Lee R Berger
    Research article

    Optimal decision-making requires balancing fast but error-prone and more accurate but slower decisions through adjustments of decision thresholds.

Listing Read More First Page

Further reading

    1. Cell Biology
    2. Epidemiology and global health
    Lee R Berger
    Research article

    Optimal decision-making requires balancing fast but error-prone and more accurate but slower decisions through adjustments of decision thresholds. Here, we demonstrate two distinct correlates of such speed-accuracy adjustments by recording subthalamic nucleus (STN) activity and electroencephalography in 11 Parkinson’s disease patients during a perceptual decision-making task; STN low-frequency oscillatory (LFO) activity (2–8 Hz), coupled to activity at prefrontal electrode Fz, and STN beta activity (13–30 Hz) coupled to electrodes C3/C4 close to motor cortex. These two correlates differed not only in their cortical topography and spectral characteristics but also in the relative timing of recruitment and in their precise relationship with decision thresholds. Increases of STN LFO power preceding the response predicted increased thresholds only after accuracy instructions, while cue-induced reductions of STN beta power decreased thresholds irrespective of instructions. These findings indicate that distinct neural mechanisms determine whether a decision will be made in haste or with caution.

    1. Cell Biology
    2. Epidemiology and global health
    Lee R Berger
    Research article

    Optimal decision-making requires balancing fast but error-prone and more accurate but slower decisions through adjustments of decision thresholds.

Listing Teasers

Listing of teasers

    1. Microbiology and Infectious Disease
    Meaningful alt text please.

    Quorum sensing control of Type VI secretion factors restricts the proliferation of quorum-sensing mutants

    Charlotte Majerczyk et al.
    Quorum-sensing control of Burkholderia thailandensis toxin and immunity pairs serves to police quorum-sensing mutants and may represent a general strategy whereby cooperators can police mutants.
  1. Mapping global environmental suitability for Zika virus

    Jane P Messina et al
  2. Meaningful alt text please.

    The global antigenic diversity of swine influenza A viruses

    Nicola S Lewis et al.
    Swine populations worldwide are sporadically infected by influenza viruses from humans and birds leading to geographically heterogeneous swine influenza virus populations that pose epizootic and pandemic threats.

Listing Teasers First Page

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    1. Microbiology and Infectious Disease
    Meaningful alt text please.

    Quorum sensing control of Type VI secretion factors restricts the proliferation of quorum-sensing mutants

    Charlotte Majerczyk et al.
    Quorum-sensing control of Burkholderia thailandensis toxin and immunity pairs serves to police quorum-sensing mutants and may represent a general strategy whereby cooperators can police mutants.
  1. Mapping global environmental suitability for Zika virus

    Jane P Messina et al
  2. Meaningful alt text please.

    The global antigenic diversity of swine influenza A viruses

    Nicola S Lewis et al.
    Swine populations worldwide are sporadically infected by influenza viruses from humans and birds leading to geographically heterogeneous swine influenza virus populations that pose epizootic and pandemic threats.

Listing Teasers Highlights

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    1. Microbiology and Infectious Disease
    Meaningful alt text please.

    Quorum sensing control of Type VI secretion factors restricts the proliferation of quorum-sensing mutants

    Charlotte Majerczyk et al.
    Quorum-sensing control of Burkholderia thailandensis toxin and immunity pairs serves to police quorum-sensing mutants and may represent a general strategy whereby cooperators can police mutants.
  1. Mapping global environmental suitability for Zika virus

    Jane P Messina et al
  2. Meaningful alt text please.

    The global antigenic diversity of swine influenza A viruses

    Nicola S Lewis et al.
    Swine populations worldwide are sporadically infected by influenza viruses from humans and birds leading to geographically heterogeneous swine influenza virus populations that pose epizootic and pandemic threats.

Read More Item

    1. Cell Biology
    2. Epidemiology and global health
    Lee R Berger
    Research article

    Optimal decision-making requires balancing fast but error-prone and more accurate but slower decisions through adjustments of decision thresholds. Here, we demonstrate two distinct correlates of such speed-accuracy adjustments by recording subthalamic nucleus (STN) activity and electroencephalography in 11 Parkinson’s disease patients during a perceptual decision-making task; STN low-frequency oscillatory (LFO) activity (2–8 Hz), coupled to activity at prefrontal electrode Fz, and STN beta activity (13–30 Hz) coupled to electrodes C3/C4 close to motor cortex. These two correlates differed not only in their cortical topography and spectral characteristics but also in the relative timing of recruitment and in their precise relationship with decision thresholds. Increases of STN LFO power preceding the response predicted increased thresholds only after accuracy instructions, while cue-induced reductions of STN beta power decreased thresholds irrespective of instructions. These findings indicate that distinct neural mechanisms determine whether a decision will be made in haste or with caution.

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